| Buffalo at Baltimore | 1:00 pm | CBS | M&T Bank Stadium |
| Cincinnati at Indianapolis | 1:00 pm | CBS | Lucas Oil Stadium |
| Houston at New England | 1:00 pm | CBS | Gillette Stadium |
| Jacksonville at N.Y. Giants | 1:00 pm | FOX | MetLife Stadium |
| Pittsburgh at Cleveland | 1:00 pm | CBS | FirstEnergy Stadium |
| San Francisco at Minnesota | 1:00 pm | FOX | U.S. Bank Stadium |
| Tampa Bay at New Orleans | 1:00 pm | FOX | Mercedes-Benz Superdome |
| Tennessee at Miami | 1:00 pm | FOX | Hard Rock Stadium |
| Kansas City at L.A. Chargers | 4:05 pm | CBS | StubHub Center |
| Dallas at Carolina | 4:25 pm | FOX | Bank of America Stadium |
| Seattle at Denver | 4:25 pm | FOX | Sports Authority Field at Mile High |
| Washington at Arizona | 4:25 pm | FOX | University of Phoenix Stadium |
| Chicago at Green Bay | 8:20 pm | NBC | Lambeau Field |
